Na + -Ca 2+ Exchange
نویسندگان
چکیده
منابع مشابه
Na-Ca or Na-Ca-K exchange in rod photoreceptors.
Remarkably dynamic Ca z ÷ fluxes control Ca 2 ÷ homeostasis in the outer segments of vertebrate rod photoreceptors (ROS). Ca 2 ÷ fluxes are believed to be carried by only two different membrane proteins embedded in the ROS plasma membrane; these two proteins as well as some of the other main molecular components of ROS are schematically depicted in Fig. 1. ROS are the sites of the process of vi...
متن کاملCardiac Na(+)-Ca(2+) exchange: molecular and pharmacological aspects.
The Na(+)-Ca(2+) exchanger (NCX) is one of the essential regulators of Ca(2+) homeostasis in cardiomyocytes and thus an important modulator of the cardiac contractile function. The purpose of this review is to survey recent advances in cardiac NCX research, with particular emphasis on molecular and pharmacological aspects. The NCX function is thought to be regulated by a variety of cellular fac...
متن کاملEffects of Phospholipase C on the Na + - Ca 2 + Exchange and Ca 2 + Permeability of Cardiac
We have examined the effects of phospholipase C pretreatment on Ca2+ transport in highly purified canine cardiac sarcolemmal vesicles. Na+-Ca2+ exchange, measured as Nai+-dependent Caz+ uptake, is stimulated when 10-70% of the membrane phospholipid has been hydrolyzed. Although the phospholipase C treatment also increases sarcolemmal passive Ca2+ flux, the membrane maintains a sufficient permea...
متن کاملNa(+)/Ca(2+) exchange facilitates Ca(2+)-dependent activation of endothelial nitric-oxide synthase.
Recent evidence suggests the expression of a Na(+)/Ca(2+) exchanger (NCX) in vascular endothelial cells. To elucidate the functional role of endothelial NCX, we studied Ca(2+) signaling and Ca(2+)-dependent activation of endothelial nitric-oxide synthase (eNOS) at normal, physiological Na(+) gradients and after loading of endothelial cells with Na(+) ions using the ionophore monensin. Monensin-...
متن کاملEnhanced Ca(2+)-activated Na(+)-Ca(2+) exchange activity in canine pacing-induced heart failure.
Defective excitation-contraction coupling in heart failure is generally associated with both a reduction in sarcoplasmic reticulum (SR) Ca(2+) uptake and a greater dependence on transsarcolemmal Na(+)-Ca(2+) exchange (NCX) for Ca(2+) removal. Although a relative increase in NCX is expected when SR function is impaired, few and contradictory studies have addressed whether there is an absolute in...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2002
ISSN: 0009-7330,1524-4571
DOI: 10.1161/res.90.2.118